Last updated on Feb. 22, 2010
Gene Kinetics of the Cell Proliferation in Vivo (pdf, 350 kb) Why are the control mechanisms of cell proliferation elusive? Because they are kinetic! Find out how the proliferation of biological cells may be simulated based on only five equations relating to 1000 pages of bench-top results! (19 equations, 132 literature references)Rethinking Thermal Radiation by Using Its Mathematical Form in Gene Kinetics, Cognitive Psychology, and Economics. (pdf, 240kb, 1999-2007, republished here on Jan 31, 2008) Find out how gene transcription may be similar to a black hole in the universe or to the abstract concept in mental cognition!. The Gordian Knot of Quiescence, Commitment, and Clonal Expansion. (html-link to pdf, 318kb, 20 pp., published on Feb. 22, 2010)
Software Downloads in Gene Kinetics
GeneDryLab Vers. 1.0
Size: 0.1 MB
Description: Displays graphs of transcription (mRNA) and gene expression (enzyme or pathway) in an ongoing cell cycle or in a contact-inhibited (quiescent) biological cell based on the theory presented in the article "Gene Kinetics of the Cell Proliferation in Vivo" available at the link above. User may choose to display 2-8 consecutively expressed genes and to alter their expression in two consecutive cell cycles by way of the function variables 1) Effective decay of gene-activating principle (e.g. inducer or lack of suppressor), 2) Steady-state level of metabolites of the gene product that induces the next gene in the sequence, 3) Operon-specific restriction enzymes or cytoplasmic RNAses and hydrolases, 4) Constitutive mRNA, 5) Transcript-specific, inhibitory mRNA, 6) Gene amplification of any gene, 6) Operon-specific or un-specific proteases, 7) General anabolic capacity. Some flexibility regarding emulation of mitosis and contact inhibition is also provided. Furthermore, after 2-3 cell cycles, user may choose to display cell cycle phase lengths, cell cycle duration, and peak values of mRNA and pathway as modulated by variable settings.
Users: Software is intended for use in molecular biology, cell biology, pharmacology, and oncology for the purpose of predicting cell behavior and gene expression in vivo at the cellular level and designing or interpreting results of bench-top experiments.
System Requirements: Operating System: Windows ® (Win 95, 98, 2000, NT, XP), MS-DOS, Linux with DOSEMU, Ver. 1.2.2-1 and freedos, binary distribution (Ver. 1.0 has been tested for basic functionality with RedHat, 8.0). Processor: 8086/8088, ~200 MHz or faster. System must be capable of screen display in VGA mode (cf. monitor manual). Windows Vista ® is not capable of running this program on its own, however it can be made to run inside a 'DOSBOX 0.72' (www.dosbox.com) environment. More recently, www.dosbox.com claims that DOS programs can be run whole screen inside the DOSBOX environment in Win Vista and Win 7 including the 64bit versions (2012, July 4).
Download the fully functional freeware GeneDryLab, Vers. 1.0 HERE
INSTRUCTIONS: Click on the link above and choose the option "Save to Disk". Once download is complete, double-click on the program icon and follow the instructions. Be careful to check if your system is capable of running in VGA mode before using the program (most modern monitors are). Installing is not necessary, uninstall by dragging the icon to the paper bin. The program makes extensive use of the available memory within MS-DOS. Local settings that decrease the memory available in MS-DOS may hamper the functionality of the program. Please note that variables only can be altered at the point of termination of a cell cycle! Comprehensive information about the functionality of the program is available at HERE
DISCLAIMER: The user only must decide whether or not the program can be run safely on the local system. No guarantee can be given that the software is error-free although all known errors were removed prior to publishing (give 10 sec to each combination of variable shift up or down and it would take at least as long as the age of the universe to certify that the program is free of errors). No guarantee can be given that the background theory is applicable in the local context. The user only must choose to evaluate the results given by the computations by reference to real bench-top data.
WARRANTY: No registry editing, machine language, or commands well known to be potentially harmful to a computer were used with the BASIC programming code. The graphic and sound effects have been kept to a minimum. Programming commands or any routines involving the communications port have not been used at all.
COPYRIGHT: The software is based on copyright-protected scripts. It is available on diskette or CD. The downloadable program GeneDryLab, Vers. 1.0 may be evaluated, used, and redistributed freely provided it is not altered in any way. Reselling the program for profit is not allowed.